Like all cancer cell lines, it is immortal and can divide indefinitely.A unique aspect of the KBM-7 cell line is that it is near-haploid, meaning it contains only one copy for most of its chromosomes.Human chromosomes are typically diploid, meaning that there are two copies of … The Data Explorer tab enable to retrieve all the K562 cells sub-cellular and sub-nuclear short RNA fractions from ENCODE. Beta-carboline MAO inhibitors, such as harmine, bind with DNA and also exhibit anti-tumor properties. Sensitivity of K562 and HL-60 Cells to Edelfosine, an Ether Lipid Drug, Correlates with Production of Reactive Oxygen Species ; Last edited on 17 September 2020, at 05:54. b. There is a G -> A mutation in codon 273 of the p53 gene resulting in an Arg -> His substitution and a C -> T mutation in codon 309 resulting in a Pro -> Ser substitution. This could explain the cytotoxic effect of Peganum harmala on these cells." Midkine (MK or MDK), also known as neurite growth-promoting factor 2 (NEGF2), is a protein that in humans is encoded by the MDK gene. A total of 105 potential Myb gene … To gain further insight to this process, we used transcript profiling in K562 cells expressing a dominant-negative Myb (MERT) protein. Fraction of reads containing each of the two alleles of SNP rs1053036 in NR_125431 in K562 genomic DNA (left) and K562 RNA-seq reads (right). KBM-7 cells are a chronic myelogenous leukemia (CML) cell line used for biomedical research. We genetically modified K562 cells to express two NK stimu- This retrieves 19 … This locus in K562 cells is most likely triploid. "Harmine showed cytotoxicity against HL60 and K562 cell lines. Media in category "K562 cells" The following 7 files are in this category, out of 7 total. Basic leucine zipper transcription factor, ATF-like 2 is a protein that, in humans, is encoded by the BATF2 gene. Harmine has been shown to bind one hundred times more effectively than its close analogue harmaline. G-protein coupled receptor 31 also known as 12-(S)-HETE receptor is a protein that in humans is encoded by the GPR31 gene.The human gene is located on chromosome 6q27 and encodes a G-protein coupled receptor protein composed of 319 amino acids. We first select the "Expression experiments" sub-tab and search for wgEncodeCshlShortRnaSeqK562. این سلول‌ها جزء دستگاه ایمنی ذاتی بدن هستند. ŸFLAG標定的hZIP1位在許多皮質細胞的內質網上，包括了Caco-2，更近一步透過在PC-3前列腺細胞操作hZIP1抗體可以更精確的證明這件事。 其他可能存在的Zinc transporter بیعی(به انگلیسی: Natural killer cell) (NK cells) لنفوسیتهایی از دستگاه ایمنی بدن هستند که در ایمنی سلولی و ایمنی ذاتی (Innate immune system) دخیل هستند. Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. Content is available under CC BY-SA 3.0 unless otherwise noted. Contact with K562 cells, a cell line derived from a pa tient with myeloid blast crisis of chronic myelogenous leukemia and bearing the BCR-ABL1translocation, is known to in-duce modest proliferations of NK cells [28, 32], and aug-ment NK cell proliferation in response to IL-15 [24]. Retrieving K562 cells sub-cellular and sub-nuclear short RNA fractions from ENCODE DEX based datasource selection. The c-myb proto-oncogene has been implicated in leukemogenesis, but possible mechanisms remain ill defined. The cells express elevated levels of p53 protein. The cells are positive for keratin by immunoperoxidase staining.