This experiment involves a practical examination of ether synthesis. its Isolation from Guai -aid Cough Tablets. Introduction It would be beneficial if you review the chapter on substitution reactions in your textbook prior to lab. Introduction. Objective: The goal of this experiment was to form an ether compound with sodium ethoxide and 1-bromobutane as the reagents. 3. Post-lab questions: 1. H. 2. Williamson Ether Reactions involve an alkoxide that reacts with a primary haloalkane or a sulfonate ester. TLC Analysis 1. SN1 SN2 (Williamson Ether Synthesis) or Chemical Safety Information: SN1 2-methyl-2-butanol hydrochloric acid 2-chloro-2-methyl-butane sodium chloride sodium bicarbonate magnesium sulfate deuterated chloroform SN2 4-methoxyphenol 4-tert-butylphenol para-hydroxyacetophenone 4-nitrophenol 3-nitrophenol para-bromobenzyl bromide KOH ethanol 1-bromobutane 1-bromopropane para … 11 in the 9th edition McMurry textbook. ... report. Comment on this in the results and discussion section of your formal report. 19. Question: Lab Report 3. 3. 1 12. View Entire Discussion (0 Comments) More posts from the OrganicChemistry community. simplest way to synthesize an ether is to have an alkoxide react with a primary haloalkane or a sulfonate ester under typical SN2 conditions. OH O CH. This is Ch. (3 Points) Safety Information Provide Information As For The Safety Of Chemicals Being Used. Background of the experiment ( 2 paragraphs) Reaction scheme and step by step mechanism using arrows and the column chromatography; calculate the yield of all of the components and show your work; discussion ( the discussion questions are based on the procedure) and show your work if theres any calculations O O CH. Williamson ether synthesis. Cl OH OH. Posted by 2 days ago. The scientist who developed this reaction, Alexander W. Williamson, was a professor at University College in London in the latter part of the 1800's.This reaction has been around a while! Help with Williamson ether synthesis. Experiment 12 – The Williamson Ether Synthesis pg. The lab report should include. hide. Dissolve your saved product from above in a small amount of ethyl acetate. Be the first to share what you think! Your Ether Is... (5 Points) Materials And Methods Reactants List All The Reactants Used For This Synthesis. Posted by 9 days ago. ... save. List Three Limitations Of The Williamson Ether Synthesis And Explain How Our Choice Of Reagents Circumvents Those Limitations. The purification was tested with an NMR spectroscopy which is used as a tool for determining structure. In chemistry, ethers are important compounds applied in a variety of ways including but not limited to dissolution of organic compounds, and formation of organic linkages. O, heat. Scheme 1. guaicol ua if e ns. The Williamson Ether Synthesis can specifically be found in sections 17-2 and 18-2. Williamson Ether Synthesis Lab. The same material will also be isolated from over the counter tablets via a simple extraction. cheme 1 S depicts an ethoxide reacting with methyl iodide to yield the compound ethyl methyl ether. In week 2, this product was extracted and purified to test the purify of the ether that was formed. 19. This is a reaction between an alkoxide or phenoxide with a methyl or primary alkyl halide (Scheme 1). Williamson Ether Synthesis of an Expectorant – Guaifenesin – and. O O CH. 2. Lab manual says react phenolate with butyl iodide, can I use butyl bromide instead ... no comments yet. Question: Post Lab Questions: Williamson Ether Synthesis (6 Pts) In Your Lab Report Answer The Following Questions And Briefly Explain Your Answers: 1. NaOH. In this experiment, Guaifenesin will be simultaneously synthesized in the laboratory and isolated from a Guai -aid cough tablet. The Williamson Ether Synthesis A. Chem 343-09 October 29, 2020 I. Williamson Ether Synthesis II. The synthesis of phenacetin from acetaminophen will be accomplished via the Williamsonether - synthesis. report. Williamson ether synthesis is the most widely and simplest method in ether synthesis. OH HO. 3. Williamson Ether Synthesis. In this experiment, (±)-3-chloro-1,2-propane-diol will be allowed to react with the conjugate base of Guaicol (2-methoxyphenol) via an S N2 reaction to provide guaifenesin as a racemic mixture.